Kübra’s paper is published in Journal of Biological Rhythm.This paper is entitled “Diurnal Changes in Capecitabine Clock-Controlled Metabolism Enzymes Are Responsible for Its Pharmacokinetics in Male Mice” and highlights the importance of capecitabine administration time to increase the efficacy with minimum adverse effects .
Metabolism pathway of capecitabine. Capecitabine is converted to 5′-deoxy-5-fluorocytidine (5′DFCR) by carboxylesterases (CESs), which are mainly located in the liver and then 5′DFCR is converted to 5′-deoxy-5-fluorouridine (5′DFUR) by cytidine deaminase (CDA) in the liver and tumor. 5′DFUR is converted to 5-FU (5-fluorouracil) by pyrimidine phosphorylases (PyNPase) in the liver and tumor. Finally, 5-FU is catabolized by dihydropyrimidine dehydrogenase (DPD) in the liver.
