Just Published Paper

Sibel’s paper titled “CRY1-CBS binding regulates circadian clock function and metabolism” is accepted to be published in The FEBS Journal.

This paper provide a novel insight that CBS-CRY1 binding provides a post-translational switch to modulate cellular circadian physiology and metabolic control.

The mechanisms coupling circadian rhythms and metabolism remain poorly understood. We find that the core circadian protein Cryptochrome 1 (CRY1) binds Cystathionine β-synthase (CBS), a central enzyme in one-carbon metabolism. This binding modulates the activity of both proteins. During the active phase, CBS augments CRY1 mediated repression of BMAL1/CLOCK driven transcription. During the rest phase, CRY1 increases CBS enzymatic activity.