Published Paper

Yağmur and Darya’s paper titled “A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude” is published in Journal of Biological Chemistry. 295(11):3518-3531

This paper describe the discovery of the small molecules has potential to be used as drug to eliminate circadian clock related diseases in ageing.

A schematic presentation of CLK8 affecting CLOCK and the circadian rhythm. CLOCK and BMAL1 are dynamically interacting. When CLK8 is present, it binds to CLOCK and reduces CLOCK and BMAL1 interaction. Upon binding of CLK8 to CLOCK, the translocation of the CLOCK into nucleus abolished. At the cellular level, CLK8 enhances the amplitude of the circadian rhythm. The role of CLOCK in regulating the circadian clock amplitude can be investigated using CLK8 to transiently modulate CLOCK. Thin line indicates reduction in strength of positive arm of TTFL while Thick line represent enhanced strength of negative arm of TTFL